Promotes the uptake of glucose into cells

Stimulates the breakdown of glycogen to glucose in the liver.

Increases the production of glucagon in the pancreas.

Insulin increases lipolysis and promotes the breakdown of stored glycogen

Metformin should be taken empty stomach before evening meal

Metformin has higher hypoglycaemic risk than Sulphonylurea

It is the same as angiotensin receptor blocker

Inhibits leukocyte migration and activity.

Enhances immune response to inflammation.

Administer the drug undiluted at a rapid rate.

Infuse through a 0.22-micron in-line filter.

Co-administer with intravenous calcium to prevent hypocalcemia.

Premix the medication with a dextrose-containing solution.

It can be used in patients with severe renal impairment

Discontinuation of metformin is needed before IV contrast

It can be used for treating T1 and T2 diabetes

Family history of type 2 diabetes mellitus

Aged over 35 years and smoking more than 15 cigarettes per day

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