Inhibits COX-1 and COX-2 enzymes, decreasing prostaglandin synthesis

Increases COX-1 and COX-2 enzymes, increasing prostaglandin synthesis

Inhibits lipoxygenase enzyme, decreasing leukotriene synthesis

Inhibits cyclooxygenase enzymes, decreasing leukotriene synthesis

Metformin should be taken empty stomach before evening meal

Metformin has higher hypoglycaemic risk than Sulphonylurea

Inhibits leukocyte migration and activity.

Enhances immune response to inflammation.

It is the same as angiotensin receptor blocker

Administer the drug undiluted at a rapid rate.

Infuse through a 0.22-micron in-line filter.

Co-administer with intravenous calcium to prevent hypocalcemia.

Premix the medication with a dextrose-containing solution.

It can be used in patients with severe renal impairment

Discontinuation of metformin is needed before IV contrast

It can be used for treating T1 and T2 diabetes

Family history of type 2 diabetes mellitus

Aged over 35 years and smoking more than 15 cigarettes per day

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